Dietary fibre acts on brain to suppress appetite

Mouse study suggests that brain activity, not gut hormones, accounts for fibre’s weight-control action.

People have long been told that a diet high in fibre can help to fight obesity, but how it does so has been unclear. A study of mouse metabolism now suggests that a product of fibre fermentation may be directly affecting the hypothalamus, a region of the brain involved in regulating appetite. Read more in Nature.